Many studies have revealed that high ICAM-1 expression promotes the occurrence, metastasis, and poor outcome of many kinds of carcinoma such as cervical [21], hepatocellular [8], gastric [20], and prostate cancer [22] and that it might be induced by NF-κB- and AP-1-mediated pathways [23]. The gene discussed is NFKB1; the disease is prostate cancer.