CYP1A2 and Cognitive impairment: Specifically, chronic nicotine exposure may (1) precipitate frequent relapse in patients with SSD on clozapine augmentation or monotherapy by increasing the metabolism of clozapine via induction of the cytochrome P450 1A2 subenzyme and (2) indirectly promote medication nonadherence as studies have shown that it attenuates the cognitive impairment associated with the use of antipsychotics including clozapine, haloperidol, and risperidone [19, 20].