The results indicated that the NLRP3 inflammasome expression levels with alcohol consumption (IL-18, χ2 = 5.073, P = 0.024), the stage of LSCC (NLRP3, χ2 = 9.526, P = 0.022; IL-18, χ2 = 12.089, P = 0.007, IL-1β, χ2 = 10.190, P = 0.017; ASC, χ2 = 23.659, P < 0.001; caspase-1, χ2 = 7.916, P = 0.049), histological grade (NLRP3, χ2 = 7.708, P = 0.029; IL-18, χ2 = 7.267, P = 0.023; IL-1β, χ2 = 13.959, P = 0.001), and tumor diameter (NLRP3, χ2 = 4.007, P = 0.045; IL-18, χ2 = 5.342, P = 0.021; ASC, χ2 = 5.244, P = 0.022) exhibited significant differences. The gene discussed is NLRP3; the disease is neoplasm.