Univariate Cox regression analysis showed that LSCC patients with stage of LSCC (hazard ratio (HR) = 1.517, 95% confidence interval (CI) 1.091–2.111, P = 0.013), histological grade (HR = 2.119, 95%CI 1.241–3.620, P = 0.006), tumor diameter (HR = 2.686, 95%CI 1.385–5.211 P = 0.003), NLRP3 (HR = 2.196, 95%CI 1.183–4.076 P = 0.013), IL-18 (HR = 2.066, 95%CI 1.085–3.932 P = 0.027), IL-1β (HR = 2.041, 95%CI 1.073–3.882 P = 0.030), and ASC (HR = 1.946, 95%CI 1.010–3.748, P = 0.047) had an increased risk of LSCC progression (Table 5). Here, NLRP3 is linked to neoplasm.