NLRP3 and neoplasm: Multivariate Cox regression analysis showed that LSCC patients with histological grade (HR = 1.873, 95%CI 1.021–3.436, P = 0.043), tumor diameter (HR = 2.321, 95%CI 1.160–4.644, P = 0.017), NLRP3 (HR = 1.940, 95%CI 1.026–3.667, P = 0.041), and IL-1β (HR = 2.128, 95%CI 1.046–4.332, P = 0.037) also had an increased risk of LSCC progression (Table 5).