On the contrary, the Aurora B and CSF1R inhibition showed antagonistic interaction, which is supported by the study33 of Patsialou et al., 2014, in which the CSF1R signaling was shown to mediate a switch between the invasion and proliferation states via the TGF-β pathway in MDA-MB-231, and thus may provide new insights into the tumor progression. The gene discussed is TGFB1; the disease is neoplasm.