In the present study, we established a DDP-resistant cervical adenocarcinoma cell line, HeLa/DDP, and then explored the expression of p16, phosphorylated ERK1/2 (pERK1/2), ERK1/2 and MDR1 in HeLa and HeLa/DDP cells. Here, CDKN2A is linked to cervical adenocarcinoma.