RNASE1 and familial pancreatic carcinoma: Bovine seminal RNase (BS-RNase) triggers an autophagic cell death process in pancreatic cancer cells mediated by BECN1 induction; and onconase, a RNaseA superfamily member proposed for chemotherapy, inhibits the proliferation of cancer cells through the ROS/Akt/mTOR pathway (33, 75).