CRTAM and infection: Histological analysis of the intestine revealed that Crtam−/− mice had more ileal pathology than did WT mice after infection with T. gondii; Crtam−/− mice displayed loss of epithelial integrity, mucosal and submucosal edema, altered villus architecture, and moderate inflammatory infiltrates (Figures 1D,E), the colon was equally affected in WT and Crtam−/− mice (Figure 1E; Figure S1).