GRIN2A mutation is commonly associated with childhood epilepsy syndromes within epilepsy-aphasia spectrum, such as benign epilepsy with centrotemporal spikes (BECTS), Landau-Kleffner syndrome (LKS), and epileptic encephalopathy with continuous-spike-and-waves-during-slow-wave-sleep (CSWSS) (159, 160), whereas GRIN1, GRIN2B and GRIN2D mutations present with developmental delay and more severe phenotypes of epilepsy (161, 162). This evidence concerns the gene GRIN2D and Landau-Kleffner syndrome.