Increased glutamine synthetase together with normal expression of excitatory amino acid transporter 2 responsible for over 90% of glutamate reuptake within the CNS in the platelets of ALS patients, involving glutamate excitotoxicity in the pathogenesis of ALS has also been reported (Bos et al., 2006). This evidence concerns the gene GLUL and amyotrophic lateral sclerosis.