In this work miR-34b and miR-34c were demonstrated to alter the mitochondrial function in neuronal cells through the inhibition of protein deglycase (DJ1, also known as PARK7), a redox-sensitive protein which triggers activation of antioxidant defenses via the Nrf2/ARE system, and Parkin (PRKN), which, together with PARK7, are associated with familial forms of PD (Dodson and Guo, 2007). Here, PRKN is linked to Parkinson disease.