As the pro-inflammatory cytokines, TNF-α, IFN-γ, and IL-1β are present in MS lesions (Codarri et al., 2010; Mendiola and Cardona, 2018) and influence OPC maturation (Xie et al., 2016; Valentin-Torres et al., 2018) and therefore remyelination, we next analyzed whether these cytokines may modulate TG2 expression in OPCs. This evidence concerns the gene TNF and myeloid sarcoma.