Given that Transglutaminase expression and activity is commonly detected both in diseased tissues with inflammation and cells with inflammatory stress (Kuncio et al., 1998; Johnson et al., 2001; Kim, 2006), and TG2 expression is regulated by inflammatory mediators (van Strien et al., 2011b; Espitia Pinzón et al., 2017a), we next examined the effect of inflammatory mediators that are present in MS lesions on TG2 expression in OPCs and immature OLGs. The gene discussed is TGM2; the disease is myeloid sarcoma.