The prevailing idea on the dual effects exerted by VEGF states that the dominant actions of this trophic factor, whether neuroprotective or detrimental, are chiefly dictated by the timing, dosage, and route of administration in experimental models of stroke (Wittko-Schneider et al., 2013; Geiseler and Morland, 2018). This evidence concerns the gene VEGFA and stroke disorder.