Protein analysis identified a significant increase of VEGF-B in CSF and the ischemic hemispheres, with increased VEGFR1 activation that also correlated with an increase in Akt phosphorylation, whereas an increase in VEGF in the contralateral hemisphere correlates with a significant increase in vascular density 7 days post-stroke (Guan et al., 2011). Here, AKT1 is linked to stroke disorder.