MAPT and Alzheimer disease: Single neuron expression profiling investigations have addressed the extent to which levels of transcripts encoding neurotrophin receptors are altered in individual nbM neurons labeled for the pretangle marker pS422+, the late stage caspase-cleaved tau marker TauC3+ or pS422/TauC3+ compared to unlabeled neurons obtained from NCI, MCI, and AD cases provided by the RROS (Tiernan et al., 2018a).