MAPT and Alzheimer disease: We previously performed antibody imunostaining for TOC1 (Patterson et al., 2011; Ward et al., 2013) and p75NTR to quantify pretangle tau oligomeric assemblies, which most likely are the more neurotoxic species of tau (Berger et al., 2007; Maeda et al., 2007; Kopeikina et al., 2011; Lasagna-Reeves et al., 2012; Sahara et al., 2013) within CBF neurons during the progression of AD (Tiernan et al., 2018b).