Alterations in proNGF, the NGF precursor protein, has received extensive study in clinical pathological investigation of components of the cortical DMN, which includes frontal cortex, posterior cingulate, precuneus, superior temporal cortex (Perez et al., 2015), and the hippocampus (Mufson et al., 2012b), which contribute to cognitive dysfunction during the progression of AD (Sperling et al., 2014). The gene discussed is NGF; the disease is Alzheimer disease.