Several HDACs are related with cellular events dysfunctional in AD, including endoplasmic reticulum stress (HDAC4) (Shen et al., 2016), autophagy (HDAC6) (Pandey et al., 2007), mitochondrial transport (HDAC6) (Chen et al., 2010), tau hyperphosphorylation (HDAC6) (Ding et al., 2008) and Aβ and tau accumulation (SIRT1) (Julien et al., 2009; Lalla and Donmez, 2013). This evidence concerns the gene MAPT and Alzheimer disease.