Studies comparing gene expression profiles of CBF neurons identified by p75NTR (Mufson et al., 1989) display a dysregulation of select synaptic-related markers (e.g., downregulation of synaptophysin and synaptotagmin 1 among others), protein phosphatases/kinases (e.g., downregulation of protein phosphatases 1 and 2 subunits and upregulation of cyclin-dependent kinase 5) along with endosomal-lysosomal markers (e.g., upregulation of lysosomal markers cathepsin D, rab4, rab5, and rab7) in MCI and AD compared to age-matched NCI subjects (Ginsberg et al., 2006a,b, 2010; Counts et al., 2011). Here, NGFR is linked to Alzheimer disease.