MAPT and Alzheimer disease: Of particular interest was the finding that phospho-JNK and the density of AT8 tau-positive NFTs and neuropil threads (NTs) are positively related during the onset of AD, supporting the observation that JNK activation mediates tau phosphorylation at Ser202/Thr205 (AT8 site) (Goedert et al., 1997; Reynolds et al., 1997).