Naturallyidentified Hydroxamic acid HDAC inhibitor was Trichostatin A(TSA) and SAHA (Suberoylanilide hydroxamic acid or Vorinostat(Zolinza)) is structurally similar to TSA was first HDAC inhibitorapproved for the treatment of refractory cutaneous T-celllymphoma by Food and Drug Administration (FDA) in October2006 10-11. The gene discussed is HDAC9; the disease is T-cell non-Hodgkin lymphoma.