FOXO3 and neoplasm: In agreement with the notion that cytoplasmic FOXO3 being the functional form of the tumour suppressor, previous findings also have demonstrated that PERK and P-eIF2α levels are significantly associated with higher histological grades, higher numbers of tumour-infiltrating lymphocytes (TILs), which are good prognostic markers in human epidermal growth factor receptor 2 (HER2)-positive breast cancer tissues.