CFTR and cystic fibrosis: Recently, it has been reported that the naturally occurring polypeptide thymosin α-1 (Tα-1) rescues CFTR maturation, stability, and activity, thereby correcting the pathological abnormalities of F508del-CFTR in vitro (in CFBE41o- cells and in primary human bronchial epithelial cells), and in vivo in a CF murine model38.