SOAT1 and cancer: In addition, copy number gain of the whole chromosome 12 was observed in 48% (22/46) of patients, leading to amplification of 34 cancer related genes annotated in the Catalogue of Somatic Mutations in Cancer (COSMIC) database and signaling pathways including MAPK (q = 0.001), JAK/STAT (q = 0.014), and cell cycle (q = 0.032) (Supplementary Data 8).