Among them, genes with a prevalence of at least 5% included four tumor suppressor genes previously implicated in cancer (TP53, NOTCH1, MGA, and PTPRD), one negative regulator of NF-κB pathway (TRAF3), one epigenetic modifier (KMT2C), and one laminin subunit essential for basement membrane (LAMA4). This evidence concerns the gene NOTCH1 and cancer.