Interestingly, the wild-type KIT receptor, once activated by its ligand in both TF-1 and OCI-AML3 AML cells, induced, as observed in constitutively activated KITD816V mutant cells, (Supplementary Fig. S4A–E) autophagy and activation of STAT3, ERK, and AKT pathways (Supplementary Fig. S4F). Here, STAT3 is linked to acute myeloid leukemia.