AKT1 and acute myeloid leukemia: Interestingly, the wild-type KIT receptor, once activated by its ligand in both TF-1 and OCI-AML3 AML cells, induced, as observed in constitutively activated KITD816V mutant cells, (Supplementary Fig. S4A–E) autophagy and activation of STAT3, ERK, and AKT pathways (Supplementary Fig. S4F).