We found that although ZIKV infection induced phosphorylation of IRF3 in SC, this was dramatically diminished by R428 treatment (Fig. 4G), suggesting that IFNB1 and IFNL1 transcription in SC is responsive to ZIKV genome replication and not directly modulated by Axl-IFNAR signaling. Here, IFNAR1 is linked to Zika virus infectious disease.