In MRL/lpr mice that had experienced pregnancy and lactation, we found that the effects of vancomycin and L. animalis were mostly on lupus nephritis (Figs. 1e and 3i) but not autoantibody production (Figs. 1c and 3h), which coincides with the observation in IFNγ+/− MRL/lpr mice. The gene discussed is IFNG; the disease is lupus nephritis.