In 2015, a phase I/II trial (NCT00902044) was published evaluating the safety and efficacy of HER2 CARs in 19 patients diagnosed with HER2-positive sarcomas: 16 OSs, one EWS, one primitive neuroectodermal tumor, and one desmoplastic small round cell tumor [61]. Here, ERBB2 is linked to primitive neuroectodermal tumor.