Mackall et al. describe treatment of 30 patients with EWS or alveolar RMS with autologous T cells and DCs pulsed with a peptide sequence generated from the breakpoint region identified for each tumor (EF-1 (EWS/FLI-1) or EF-2 (EWS/FLI-2) for EWS and PXFK (PAX3/FKHR) for alveolar rhabdomyosarcoma) [78]. The gene discussed is EWSR1; the disease is rhabdomyosarcoma.