PIK3R2 and immunodeficiency disease: PIK3R2 also interacts with the catalytic active PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) [40], which is implicated in the phosphoinositide 3-kinase δ syndrome (APDS) associated with senescent T cells, lymphadenopathy, and immunodeficiency [41].