To better elucidate the cooperative action of HMGA1 and FOXM1 in breast cancer cells, we performed qRT-PCR on RNA derived from the TNBC MDA-MB-231 cell line in which we silenced the expression of HMGA1 or FOXM1 or the two factors in combination (Additional file 5: Figure S2d) and we analyzed the expression of CCNE2, LEF1 and VEGFA that emerged, from our bioinformatics analysis, as common target genes of HMGA1 and FOXM1 (Additional file 4: Table S4). The gene discussed is LEF1; the disease is breast carcinoma.