VEGFA and neoplasm: We revealed that increased expression of MMP-1 (OR = 4.21, 95% CI 1.86–9.54, P = 0.0006, RE model; OR = 4.14, 95% CI 1.83–9.39, QE model), MMP-2 (OR = 11.18, 95% CI 4.26–29.30, P < 0.00001, RE model; OR = 11.24, 95% CI 4.29–29.50, QE model), MMP-9 (OR = 10.41, 95% CI 4.26–25.47, P < 0.00001, RE model; OR = 6.37, 95% CI 2.48–16.35, QE model), and VEGF (OR = 8.09, 95% CI 4.03–16.20, P < 0.00001, RE model; OR = 8.08, 95% CI 4.03–16.19, QE model) was significantly associated with tumor metastasis (Fig. 2).