This result is supported by a gene-based mapping analysis of metabolic adaptation and metabolic disease in dairy cattle, in which two genes (ENSBTAG00000031551: PRSS53; ENSBTAG00000000781: HIP1) at around 27 Mb on BTA25 were shown to be associated with blood BHB concentrations and metabolic disorders [1]. The gene discussed is HIP1; the disease is metabolic disease.