Decreased expression of genes, such as TNFRSF10B [210], MIA2 [215], and BBC3 [216], are answerable for the progression of various cancers, such as lung cancer, hepatocellular carcinoma, head, and neck cancer, but low expression of these genes may be responsible for the development of BRCA. The gene discussed is TNFRSF10B; the disease is hepatocellular carcinoma.