Methylation inactivation in tumor suppressors genes, such as MT1M [141], MT1H [142], MT1X [143], and HRK [144], is responsible for the development of various cancers, such as prostate cancer, liver cancer, colorectal cancer, and gastric cancer, but loss of these genes may be linked with the pathogenesis of BRCA. This evidence concerns the gene HRK and Familial prostate cancer.