SNP in genes, such as PPP1R15A [221], PLA2G4C [222], CMTM8 [223], and IFNL3 [224], are responsible for the growth of various cancers, such as colorectal cancer, osteosarcoma, and hepatocellular carcinoma, but SNP in these genes may be associated with the pathogenesis of BRCA. The gene discussed is IFNL3; the disease is osteosarcoma.