PLA2G4C and osteosarcoma: SNP in genes, such as PPP1R15A [221], PLA2G4C [222], CMTM8 [223], and IFNL3 [224], are responsible for the growth of various cancers, such as colorectal cancer, osteosarcoma, and hepatocellular carcinoma, but SNP in these genes may be associated with the pathogenesis of BRCA.