Genes, such as CHAF1B [169], INHBA [170], TGFB2 [171], SKA3 [172], and HELLS [173], are responsible for the invasion of various cancer cells, such as hepatocellular carcinoma, gastric cancer cells, renal cell carcinoma, prostate cancer, head and neck cancer, but these genes may be involved in the invasion of BRCA cells. Here, HELLS is linked to hereditary clear cell renal cell carcinoma.