Genes, such as POLE2 [92], RFC5 [93], MYBL2 [94], SPC25 [95], KIF23 [96], NCAPG [97], CENPU [98], and ESCO2 [99], are linked with the proliferation of various cancer cells, such as lung cancer, cervical cancer, hepatocellular carcinoma, bladder cancer, and gastric cancer, but these genes may be responsible for the proliferation of BRCA cells. The gene discussed is POLE2; the disease is hepatocellular carcinoma.