A recent work by Matsunaga and colleagues [44] addresses the relevance of the molecular clock in the microenvironment for cancer development in a mouse model, and their work shows that cells with a properly ticking biological clock that populate the tumor microenvironment could rhythmically and spontaneously regulate clock-silenced breast cancer stem cells through the circadian release of diffusible factors (i.e., WNT signaling components). Here, CLOCK is linked to neoplasm.