TP53 and central nervous system cancer: A schematic view on how the change in DNA methylation may affect CTCF related gene expression regulation is shown in Figure 1F. Another example was shown in neural stem cells model with an introduced IDH1 mutation and subsequent TP53 (tumor protein p53) and ATRX (Alpha Thalassemia/Mental Retardation Syndrome X-Linked) knockdowns, which was supposed to mimic a potential way of oncogenesis of lower grades gliomas of astrocytic origin [98].