Interestingly, when we adjusted PON lactonase activity per unit of circulating PON-1 protein levels, we noted that CKD patients with higher circulating PON lactonase activity per unit of circulating PON-1 protein demonstrated better event-free survival compared to those patients who had lower circulating PON lactonase activity per unit of circulating PON-1 protein. The gene discussed is PON1; the disease is chronic kidney disease.