Kaplan–Meier survival analyses demonstrated that the combination of lower circulating PON-1 protein levels (≤333.4 ng/mL) and higher circulating PON lactonase activity (>2073 pmol/min/mL) within CKD subjects were associated with the highest survival rates compared to those with higher circulating protein levels (>333.4 ng/mL) and lower activity (≤2073 pmol/min/mL, Figure 3). This evidence concerns the gene PON1 and chronic kidney disease.