CLCN3 and nasopharyngeal carcinoma: While several studies have suggested a relation between ASOR currents and the expression of the intracellular Cl− channels ClC-3 and ClC-7, e.g., in mouse osteoclasts [7,8], human nasopharyngeal carcinoma CNE-2Z cells [47] and HEK293 cells [7,35], others did not observe an effect on the endogenous ASOR currents upon siRNA-mediated ClC-3 or ClC-7 knock-down or ClC-3 overexpression in HEK293 and HeLa cells [9,11,35].