The role of adiponectin and its contribution to the obesity microenvironment has not yet been fully elucidated, as some human and animal studies have shown adiponectin in obesity to be lower than normal [24,25,26,27], suggesting production of adiponectin may be influenced by age, sex, location of excess adipose deposits, or overall health status. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.