Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases and is closely involved in renal physiology; it was abundantly expressed in the kidney of control mice, while in LN mouse model, the expression of this protein decreased significantly. This evidence concerns the gene SIRT1 and lobular neoplasia.