For example, dedifferentiated liposarcoma and leiomyosarcoma tumors with positive PRAME expression have been found to express reduced levels of antigen presentation molecules, such as HLA-B, HLA-C, beta-2 microglobulin (B2M), latent membrane proteins 2 and 7 (LMP2, LMP7), and transporter associated with antigen processing 2 (TAP2) [30]. The gene discussed is B2M; the disease is liposarcoma.