Modelling in vivo response upon local reactivation of p53 by intra-tumor injection of nutlin3a demonstrated elimination of tumor cells via two non-redundant p53-dependent processes: reversal of immunosuppression in tumor microenvironment and induction of immunogenic cell death, leading to the activation of dendritic cells, macrophages, and CD8+ T cells and resulting in regression of tumors distal to the nutlin3a injection site (Guo et al., 2017). The gene discussed is TP53; the disease is neoplasm.