TP53 and neoplasm: In addition to the canonical functions, such as induction of growth arrest, senescence, apoptosis and facilitation of DNA repair, non-canonical p53 activities, including anti-oxidant response, ferroptosis, regulation of metabolism and autophagy, modulation of tumor stroma and immune respons, as well as the block of invasion and metastasis, greatly contribute to anti-cancer properties of p53 (Vousden and Prives, 2009; Kastenhuber and Lowe, 2017).