Tumor regression by genetically reinstated p53 is associated with the induction of senescence and tumor clearance by macrophages and immune cells in mouse model of liver carcinoma (Xue et al., 2007), via secretion of chemokines, such as CCL2, for the recruitment of NK cells (Iannello et al., 2013). The gene discussed is TP53; the disease is hepatocellular carcinoma.