NUDCD1 also known as CML66, located on the chromosome 8q23, was one of the significant unique poor prognosticator in advanced tongue cancers along with MTFR1, IGF2BP2, TSTA3; genes that associated with survival in tongue cancer, many of these genes have been identified as involved in tumorigenesis, metastases, immune suppression in solid tumors [57–60]. This evidence concerns the gene IGF2BP2 and tongue cancer.