In PNI/ALI+ tongue cancer, the panel of TFG (tumor suppressor gene) [71], TMEM267, BRIX1 (good prognosticators), NUDCD1 and PRKCI (poor prognosticators) together could categorize the patients based on survival; PRKC1 expression is known to be associated with metastasis and poor prognosis in esophageal/ovarian cancer [72,73]. Here, BRIX1 is linked to tongue cancer.