The predictor panel in patients with PNI/ALI in laryngopharyngeal cancer consisted of AP2M1, LANCL2, PFN2, RPN1, MAP3K13, WWTR1 and IL1RAP; WWTR1 being a transcriptional coactivator regulating cell proliferation, differentiation, survival and apoptosis in oral cancer cells [74,75], while LANCL2 is associated with the EGFR pathway in many cancer [76,77]. This evidence concerns the gene RPN1 and lip and oral cavity carcinoma.