A distinct set of prognosticators were identified for HPV+ and HPV- oropharyngeal cancers; ECHDC2, GGT6, HERC5 were showed to be associated with HPV+; HERC5 has a known anti-viral activity [78] [79] and its possible role in HNSCC HPV associated cancer is yet to be studied. The gene discussed is ECHDC2; the disease is head and neck squamous cell carcinoma.