It has been reported that the antitumorigenic effects of RSV are mediated by the upregulating of the cyclic AMP response element (CRE)-binding proteins (CREB)- and activating transcription factor 2 (ATF2)-controlled target genes when HEK293 cells and HepG2 hepatoma cells treated with RSV at 20 μM [40]. Here, CREB1 is linked to hepatocellular carcinoma.