IGF1 and Hyperglycemia: First, hyperglycemia provides a high glucose fuel source that helps cancer cells maintain rapid proliferation.26 Second, up‐regulated expression of vascular endothelial growth factor (VEGF) can be induced in the hyperglycemic environment, which is a marker of enhanced tumor aggressiveness.27, 28 Third, hyperinsulinemia is another consequence of hyperglycemia, which can stimulate cell proliferation by activating insulin‐like growth factor‐I (IGF‐I).29, 30 Fourth, high levels of blood glucose may cause inflammation, which can result in the release of cytokines that can enhance cancer growth.28