We further showed that the increase in cell death was mediated via apoptosis as assessed by increased cleaved caspase‐3 levels (Fig 4D) as well as an increased fraction of Annexin V‐ and propidium iodide (PI)‐positive cells in PDXs and conventional neuroblastoma cell lines (Fig 4E and F). This evidence concerns the gene ANXA5 and neuroblastoma.