Furthermore, we detected the mechanism associated with the downregulation of HCG11. We found some potential upstream transcription factors of HCG11 from ucsc (http://genome.ucsc.edu/, date: 20180921), among which FOXP1 has been reported in human cancers as a transcription inhibitor.17, 18 Therefore, we investigated the effect of FOXP1 on HCG11 transcription. The gene discussed is HCG11; the disease is cancer.