Recently, two genome‐wide association studies conducted by Kozlitina et al. (2014) and Liu et al. (2014) found that the transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 polymorphism (a functional variant that was associated with altered gene expression levels) was not only associated with higher liver fat levels, but also associated with elevated serum levels of alanine transaminase and advanced liver fibrosis, supporting that this polymorphism might play crucial roles in the development of different types of liver diseases. The gene discussed is TM6SF2; the disease is liver disorder.