We therefore include the following covariates: treatment, sex, age, BMI, systolic blood pressure and angina grade, unstable angina, breathlessness grade, presence of a previous MI, activity level, treatment for hypertension, diabetes, smoking status, beta blockers, long acting nitrates, calcium antagonists, lipid‐lowering drugs, aspirin, ace inhibitors, and number of diseased vessels. The gene discussed is ACE; the disease is angina pectoris.