Moreover, in the presence of the human tumor cell line HT29 in the xenograft-versus-host model disease, etanercept treatment retained the ICB-mediated anti-tumor efficacy and decreased the level of alanine transaminase and aspartate transaminase in serum as well as reduced the thickness of the intestinal wall, all of which suggest a reduction in hepatitis and colitis that result from the xenograft from the host reaction. This evidence concerns the gene GPT and neoplasm.