We found the adaptive mechanism of regular aerobic exercise delaying the development of neurodegenerative diseases and lesions was to initiate miR-3557 and miR-324 to regulate one of its target Ca2+/calmodulin dependent protein kinase (CaMKs) signaling pathways and to coordinate with regulating closely related phosphatidylinositol-3-kinase (PI3K)/ protein kinase B(Akt) /mammalian target of rapamycin (mTOR) pathway protein expression, hence delaying the progression of neurodegeneration or alleviating the development of PD lesions. Here, AKT1 is linked to Parkinson disease.