AKT1 and Parkinson disease: The real-time quantitative PCR analysis showed that PI3R, Akt, and mTOR mRNA expression (Figure 4) was significantly upregulated in the lesion side compared to the no-lesion side in SED-PD (P < 0.01) and EX-PD group except Akt1 (P < 0.01). PI3R, Akt, and mTOR mRNA expression was downregulated in the no-lesion side of EX-PD compared to SED-PD.