Moreover, p53 (as a tumor suppressor protein) is the most commonly mutated pathway in tumorigenesis (Harris et al., 2018 ▶) and a crucial component in multicellular organisms, as it regulates the cell cycle progression, tumor growth and development, tumor invasion, and helps to prevent cancer via induction of apoptosis (i.e. through Bax/Bcl-2 regulation) (Aylon and Oren, 2017 ▶; Ferraz da Costa et al., 2017 ▶). Here, BCL2 is linked to cancer.