Resistance to insulin in patients with T2D has also been established as a predisposing factor of increased levels of liver enzymes such as ALT, ALP, AST, dyslipidemia, hypertension, and cardiovascular diseases (Esteghamati et al., 2008 ▶; Jyothirmayi and Kumar, 2011 ▶). This evidence concerns the gene INS and type 2 diabetes mellitus.