The previous study found <40 years patients presented with more African Americans, higher grade, higher tumor stage, more positive lymph nodes than older ones (Anders et al., 2008; Anders et al., 2009; Bharat et al., 2009), and young age patients presented with more aggressive subtypes such as HER2 and TNBC (Anders et al., 2011; Anders et al., 2008; Anderson et al., 2014; Azim Jr et al., 2012). The gene discussed is ERBB2; the disease is neoplasm.