OPA1 and breast carcinoma: In breast cancer cell, WA treatment suppressed polyethylene glycol- (PEG-) induced mitochondrial fusion and Complex III assembly accompanied by reducing the expression of mitofusin1 (Mfn1), mitofusin2 (Mfn2), and optic atrophy protein 1 (OPA1), which are involved in fusion process of mitochondria [79].