BCL2 and melanoma: In human melanoma cells, Mayola et al. showed that the apoptotic process triggered by WA included the mitochondrial-mediated apoptosis pathway associated with DNA fragmentation, Bcl-2 downregulation, caspase 9 and caspase 3 activation, Bax translocation, cytochrome c release, and disruption of mitochondrial transmembrane potential [84].