NFE2L2 and colonic neoplasm: In colon cancer HCT-116 cells, treatment with allicin enhanced hypodiploid DNA content, downregulated Bcl-2, upregulated Bax, increased cytochrome c release from mitochondria to the cytosol, and induced translocation of NF-E2-related factor-2 (Nrf2) to the nuclei, which result in apoptotic cell death [59].