CASP3 and neoplasm: JB also induced tumor cell apoptosis, downregulated the expression of glucose transporter genes (Glut1, Glut3, and Glut4), glycolysis-related kinase genes (Hk2 and Ldh-a) and antiapoptosis genes (Bcl-2, caspases 3 and 9), upregulated the mRNA expression of proapoptosis genes (Bax) and ROS production, and decreased the potential of mitochondrial membrane, ATP, and lactic acid production in mouse melanoma B16F10 cells [72].