Among genes with loss/downregulation, 4.2% (129 genes) were cancer-critical and 0.8% (25 genes) were classified as tumor suppressors in MSigDB, including TP53, APC, SMARCB1 and SMAD4 and several genes related to differentiation (CDH1, BMPR1A and FAS). This evidence concerns the gene CDH1 and neoplasm.