Among genes with loss/downregulation, 4.2% (129 genes) were cancer-critical and 0.8% (25 genes) were classified as tumor suppressors in MSigDB, including TP53, APC, SMARCB1 and SMAD4 and several genes related to differentiation (CDH1, BMPR1A and FAS). The gene discussed is APC; the disease is neoplasm.