Several TNFAIP3 and TNIP1 genetic polymorphisms have been revealed to be associated with various autoimmune disorders including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), psoriasis, etc. Hence, we were interested in exploring the associations of SNPs in TNFAIP3 and TNIP1 genes with AS susceptibility, and the five SNPs (rs610604, rs10499194, rs13207033, rs2230926 and rs6920220) in TNFAIP3 gene and four SNPs (rs2233287, rs4958881, rs3792783 and rs6889239) in TNIP1 gene were selected. Here, TNFAIP3 is linked to systemic sclerosis.