SDHC epimutations appear to be unique to specific tumour types (e.g wtGIST and PPGL)8 but further study is required to determine whether SDHC epimutations might occur in tumours with an associated hypermethylation phenotype other than SDH deficient wt GIST and PPGL. The gene discussed is SDHC; the disease is gastrointestinal stromal tumor.