Moreover, STK25 (βDiscovery = 4.97), which is differentially expressed in PrCa in comparison to benign prostatic hyperplasia (BPH)19, was significantly associated and replicated, while VPS53 (βDiscovery = −2.30), known to be regulated by the 17p13 PrCa risk locus5, had a suggestive p-value in the discovery and was nominally associated in the replication cohort. This evidence concerns the gene STK25 and benign prostatic hyperplasia.