VPS53 and Familial prostate cancer: In addition to in silico experimental support for our findings, certain genes implicated in our study replicate prior TWAS findings (BHLHA15, AGAP7, NCOA4, VPS53, FAM57A, GEMIN4, PPP1R14A)7 or prostate cancer literature, and the directions of effect in our study for previously reported cancer genes are largely concordant with the prior literature.