Moreover, imputed TMPRSS2 expression was uncorrelated with observed ERG expression in tumor-adjacent normal prostate tissue in both the training dataset (N = 471; Pearson’s r [95% CI]: 0.031 [−0.060, 0.121], Linear Regression p = 0.508; residual Shapiro-Wilks p = 0.112) as well as normal prostatic expression data from T2E-positive (N = 17; Spearman’s rho [Bootstrap 95% CI]: 0.047 [−0.484, 0.481], p = 0.859) and T2E-negative subjects (N = 28; Spearman’s rho [Bootstrap 95% CI]: −0.183 [−0.373, 0.382], p = 0.351) from TCGA. Here, TMPRSS2 is linked to neoplasm.